Development of physiological, functional, and metabolic MRI approaches - Arterial spin labeling for perfusion, and arterial blood volume - Various hemodynamic fMRI (CBF, CBV, Oxygen consumption) - Non-hemodynamic fMRI - Chemical Exchange-sensitive MRI (CEST)
Examination of underlying biophysical signal sources - fMRI signal sources (Large vs. small vessel, artery vs. vein, inter- vs. extravascular, magnetic field-dependence, and etc.) - Source of arterial spin labeling (Intra vs. extravascular) - Source of chemical exchange sensitive MR (pH, protein, neurotransmitter, conversion to concentration, and etc.)
2. Neurovascular Coupling & Systems Neuroscience
Neurovascular and neurometabolic relationship - Anesthesia-dependence - Dynamic propagation of hemodynamic and metabolic responses - Spatial point spread function - Cell-type specific, pre- vs. post-synaptic, neuron vs. astrocyte response - Role of neuromodulators (Dopamine, acetylcholine, etc)
Large scale networks with fMRI - Micro-stimulation or optogenetic stimulation induced networks - Pharmacological intervention (local and global) - Simultaneous detection of fMRI and neural activity - Rodent and non-human primate applications
